|
T15260 |
Evenamide
|
NW-3509 |
Sodium Channel
|
|
Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness. |
|
T0939 |
Phenytoin
|
Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease
,
Sodium Channel
|
|
Phenytoin (5,5-Diphenylhydantoin) is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cor... |
|
T0008 |
Phenytoin sodium
|
5,5-Diphenylhydantoin sodium salt,Diphantoine,Dilantin sodium,Diphenylhydantoin Sodium |
Virus Protease
,
Sodium Channel
|
|
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel . |
|
T19723 |
AMTB hydrochloride
|
AMTB |
TRP/TRPV Channel
|
|
AMTB hydrochloride (AMTB HCl) is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive refl... |
|
T7806 |
Licarbazepine
|
10,11-hydroxy-10,11 Dihydrocarbamezer |
Others
|
|
Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) is the pharmacologically active metabolite of oxcarbazepine, a drug indicated for the treatment of partial seizures and bipolar disorders. |
|
T9751 |
Transfluthrin
|
|
Others
|
|
Transfluthrin is a volatile pyrethroid insecticide that targets insect voltage-gated sodium channels (VGSC). |
|
T0796 |
Prilocaine hydrochloride
|
Prilocaine HCl,Propitocaine hydrochloride,Xylonest |
ATPase
,
Sodium Channel
|
|
Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions. |
|
T22361 |
Mepivacaine
|
Carbocaine |
Sodium Channel
|
|
Mepivacaine (Carbocaine) is an amide compound for local anaesthesia that causes transient loss of self-consciousness in humans or animals. mepivacaine acts by binding to specific voltage-gated sodium channels in nerve ce... |
|
T0222 |
Proparacaine hydrochloride
|
Proparacaine HCl,Proxymetacaine Hydrochloride |
Apoptosis
,
Sodium Channel
|
|
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by bindi... |
|
T0018 |
Procainamide hydrochloride
|
Procapan,Procainamide HCl,Pronestyl,Procanbid |
DNA Methyltransferase
,
Sodium Channel
,
AChR
,
Autophagy
|
|
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to... |
|
T7502 |
PF 05089771 tosylate
|
|
Sodium Channel
|
|
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8... |
|
T1496 |
Amiodarone hydrochloride
|
Amiodar,Amiodarone HCl,Nexterone |
Potassium Channel
,
Adrenergic Receptor
,
Autophagy
|
|
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C... |
|
T0267 |
Zonisamide
|
AD 810,CI 912 |
Calcium Channel
,
Sodium Channel
,
Carbonic Anhydrase
|
|
Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms... |
|
T27040 |
Clathrodin
|
|
|
|
Clathrodin is a voltage-gated sodium (NaV) channels modulator. |
|
T13830 |
Propoxycaine hydrochloride
|
|
Sodium Channel
|
|
Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels. |
|
T26564 |
ADCI
|
SGB-017,SGB017,SGB 017 |
|
|
ADCI is an inhibitor of voltage-activated sodium channels and N-methyl-D-aspartate (NMDA)-receptor-gated channels. Inhibition of sodium channels by ADCI was voltage dependent. High doses of ADCI increased dopamine metabo... |
|
T82700 |
Cn2 toxin
|
β-Mammal toxin Cn2 |
|
|
Cn2 toxin, a β-toxin, interacts with the voltage-sensing domain of voltage-gated sodium channels (NaV) [1]. |
|
T70224 |
Bupivacaine tartrate
|
|
|
|
Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intra... |
|
TP1967 |
Phrixotoxin 3
|
|
|
|
Potent blocker of voltage-gated sodium channels (IC50 values are 0.6, 42, and 72 nM for NaV1.2, NaV1.3 and NaV1.5 respectively). Blocks inward sodium currents in a voltage-dependent manner. |
|
T36813 |
Lu AE98134
|
|
|
|
Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Nav1.1 channels positive modulator. Lu AE98134 also increases the activity of Nav1.2 and Nav1.5 channels but not of Nav1.4, Nav1.6 and... |
|
T80495 |
MHuwentoxin-IV
|
|
Sodium Channel
|
|
mHuwentoxin-IV, a naturally modified form of Huwentoxin-IV, selectively inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels in dorsal root ganglion neurons with an IC50 value of 54.16 nM. Notably, the i... |
|
T75792 |
Huwentoxin XVI TFA
|
|
|
|
Huwentoxin XVI TFA, a potent analgesic derived from the Chinese tarantula Ornithoctonus huwena, acts as a highly reversible and selective antagonist of mammalian N-type calcium channels (IC 50 of ~60 nM), with no impact ... |
|
T80185 |
Huwentoxin I
|
HWTX-I |
Calcium Channel
|
|
Huwentoxin I (HWTX-I) is a peptide toxin that targets and inhibits both voltage-gated sodium channels and N-type calcium channels. It effectively inhibits sodium channels in the rat hippocampus and cockroach dorsal unpai... |
|
T69145 |
Nisoxetine
|
|
|
|
Nisoxetine, a potent and selective noradrenaline transporter (NET) inhibitor with a dissociation constant (Kd) of 0.76 nM, serves as an antidepressant and exhibits local anesthetic properties by blocking voltage-gated so... |
|
T80159 |
µ-Conotoxin KIIIA
|
|
Sodium Channel
|
|
μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2), offering potential utility in pain research [1] [2]. |
|
T68918 |
Phenytoin-d10
|
|
|
|
Phenytoin-d10 is intended for use as an internal standard for the quantification of phenytoin by GC- or LC-MS. Phenytoin is an anticonvulsant agent and active metabolite of fosphenytoin. Phenytoin is formed from fospheny... |
|
T80189 |
Hainantoxin-IV
|
HNTX-IV |
Sodium Channel
|
|
Hainantoxin-IV acts as a specific antagonist for tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels, with His28 and Lys32 being critical residues for binding to the target. This compound also features an inhibi... |
|
T82057 |
Iota-conotoxin RXIA
|
|
|
|
Iota-conotoxin RXIA, an agonist of voltage-gated sodium channels (Na v 1.2, 1.6, 1.7), has been shown to induce repetitive action potentials and seizure in the motor axons of frogs following intracranial injection in mic... |
|
T80426 |
Jingzhaotoxin-IX
|
|
Sodium Channel
|
|
Jingzhaotoxin-IX is a C-terminally amidated peptide neurotoxin consisting of 35 amino acid residues. It inhibits both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms of voltage-gated sodium channels, as well a... |
|
T35419 |
τ-Fluvalinate
|
|
|
|
τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honey... |
|
T75855 |
Phrixotoxin 3 TFA
|
|
|
|
Phrixotoxin 3 TFA is a potent inhibitor of voltage-gated sodium channels, demonstrating IC50 values of 0.6 nM for NaV1.2, 42 nM for NaV1.3, 72 nM for NaV1.4, 288 nM for NaV1.1, and 610 nM for NaV1.5, respectively. This c... |
|
T80851 |
VSTx-3
|
Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F |
|
|
VSTx-3 is a potassium voltage-gated channel (K_V) blocker, which has also been shown to be a potent tetrodotoxin-sensitive (TTX-sensitive) sodium channel inhibitor, with particular efficacy against NaV1.8 channels, as ev... |
|
T80491 |
µ-Conotoxin BuIIIB
|
Mu-Conotoxin BuIIIB |
Sodium Channel
|
|
μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB), a selective blocker of mammalian neuronal voltage-gated sodium channels (VGSC), is derived from Cone snail venom and serves as a research probe for ion channel function, as well ... |
|
T80427 |
Jingzhaotoxin-II
|
|
Sodium Channel
|
|
Jingzhaotoxin-II, a neurotoxin composed of 32 amino acid residues featuring two acidic and two basic residues, selectively inhibits voltage-gated sodium channels (VGSC), notably slowing the rapid inactivation of TTX-resi... |
|
T73337 |
Articaine
|
Hoe-045 free base |
|
|
Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furt... |
|
T37215 |
5α,6β-Dihydroxycholestanol
|
|
|
|
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR... |
